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The novel, potent and highly selective 5‐HT(4) receptor agonist YH12852 significantly improves both upper and lower gastrointestinal motility

BACKGROUND AND PURPOSE: 5‐HT(4) receptor agonists have been shown to be effective at treating various gastrointestinal tract disorders. However, a lack of selectivity against off‐targets has been a limiting factor for their clinical use. EXPERIMENTAL APPROACH: The binding affinity and selectivity of...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Br J Pharmacol
Prif Awduron: Jeong, Eun Jeong, Chung, Soo Yong, Hong, Han Na, Oh, Se‐Woong, Sim, Jae Young
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773938/
https://ncbi.nlm.nih.gov/pubmed/29139561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14096
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