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The novel, potent and highly selective 5‐HT(4) receptor agonist YH12852 significantly improves both upper and lower gastrointestinal motility
BACKGROUND AND PURPOSE: 5‐HT(4) receptor agonists have been shown to be effective at treating various gastrointestinal tract disorders. However, a lack of selectivity against off‐targets has been a limiting factor for their clinical use. EXPERIMENTAL APPROACH: The binding affinity and selectivity of...
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| Publicado no: | Br J Pharmacol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5773938/ https://ncbi.nlm.nih.gov/pubmed/29139561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14096 |
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