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Abundance of DNA adducts of 4-oxo-2-alkenals, lipid peroxidation-derived highly reactive genotoxins

Reactive oxygen species and their reaction products can damage DNA to form mutagenic lesions. Among the reactive species, lipid peroxidation-derived aldehydes react with nucleobases and form bulky exocyclic adducts. Many types of aldehyde-derived DNA adducts have been characterized, identified and d...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Biochem Nutr
Hauptverfasser: Kawai, Yoshichika, Nuka, Erika
Format: Artigo
Sprache:Inglês
Veröffentlicht: the Society for Free Radical Research Japan 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773838/
https://ncbi.nlm.nih.gov/pubmed/29362517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3164/jcbn.17-90
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