DNA Damage in Rheumatoid Arthritis: An Age-Dependent Increase in the Lipid Peroxidation-Derived DNA Adduct, Heptanone-Etheno-2′-Deoxycytidine

Objective. To evaluate what types of DNA damages are detected in rheumatoid arthritis (RA). Methods. The DNA adducts such as 8-oxo-hydroxy-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG), 1,N(6)-etheno-2′-deoxyadenosine (εdA), and heptanone-etheno-2′-deoxycytidine (HεdC) in genomic DNAs, derived from whole...

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Detalhes bibliográficos
Main Authors: Ogawa, Masako, Matsuda, Tomonari, Ogata, Atsushi, Hamasaki, Toshimitsu, Kumanogoh, Atsushi, Toyofuku, Toshihiko, Tanaka, Toshio
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814043/
https://ncbi.nlm.nih.gov/pubmed/24222845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/183487
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