Generation and Characterization of Alloantigen-Specific Regulatory T Cells For Clinical Transplant Tolerance

Donor-specific CD4(+)CD127(−)CD25(+)FOXP3(+) regulatory T cells (AgTregs) have the potential to induce clinical transplant tolerance; however, their expansion ex vivo remains challenging. We optimized a novel expansion protocol to stimulate donor-specific Tregs using soluble 4-trimer CD40 ligand (CD...

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Udgivet i:Sci Rep
Main Authors: Mathew, James M., Voss, Jessica H., McEwen, Scott T., Konieczna, Iwona, Chakraborty, Arjun, Huang, Xuemei, He, Jie, Gallon, Lorenzo, Kornbluth, Richard S., Leventhal, Joseph R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773708/
https://ncbi.nlm.nih.gov/pubmed/29348660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19621-6
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