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Redundancy of protein disulfide isomerases in the catalysis of the inactivating disulfide switch in A Disintegrin and Metalloprotease 17

A Disintegrin and Metalloprotease 17 (ADAM17) can cause the fast release of growth factors and inflammatory mediators from the cell surface. Its activity has to be turned on which occurs by various stimuli. The active form can be inactivated by a structural change in its ectodomain, related to the p...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Krossa, Sebastian, Scheidig, Axel J., Grötzinger, Joachim, Lorenzen, Inken
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773583/
https://ncbi.nlm.nih.gov/pubmed/29348576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19429-4
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