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BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes
Bloom syndrome is a cancer predisposition disorder caused by mutations in the BLM helicase gene. Cells from persons with Bloom syndrome exhibit striking genomic instability characterized by excessive sister chromatid exchange events (SCEs). We applied single-cell DNA template strand sequencing (Stra...
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| 發表在: | Nat Commun |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5773480/ https://ncbi.nlm.nih.gov/pubmed/29348659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02760-1 |
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