Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs

Bloom syndrome is a rare autosomal recessive disorder characterized by genetic instability and cancer predisposition, and caused by mutations in the gene encoding the Bloom syndrome, RecQ helicase-like (BLM) protein. To determine whether altered gene expression might be responsible for pathological...

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Autori principali: Nguyen, Giang Huong, Tang, Weiliang, Robles, Ana I., Beyer, Richard P., Gray, Lucas T., Welsh, Judith A., Schetter, Aaron J., Kumamoto, Kensuke, Wang, Xin Wei, Hickson, Ian D., Maizels, Nancy, Monnat, Raymond J., Harris, Curtis C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103369/
https://ncbi.nlm.nih.gov/pubmed/24958861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1404807111
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