Local and sustained miRNA delivery from an injectable hydrogel promotes cardiomyocyte proliferation and functional regeneration after ischemic injury

MicroRNA-based therapies that target cardiomyocyte proliferation have great potential for the treatment of myocardial infarction (MI). In previous work, we showed that the miR-302/367 cluster regulates cardiomyocyte proliferation in the prenatal and postnatal heart. Here, we describe the development...

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Vydáno v:Nat Biomed Eng
Hlavní autoři: Wang, Leo L., Liu, Ying, Chung, Jennifer J., Wang, Tao, Gaffey, Ann C., Lu, Minmin, Cavanaugh, Christina A., Zhou, Su, Kanade, Rahul, Atluri, Pavan, Morrisey, Edward E., Burdick, Jason A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773070/
https://ncbi.nlm.nih.gov/pubmed/29354322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-017-0157-y
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