Endoplasmic reticulum transport of glutathione by Sec61 is regulated by Ero1 and Bip

In the endoplasmic reticulum (ER), Ero1 catalyzes disulfide bond formation and promotes glutathione (GSH) oxidation to GSSG. Since glutathione cannot be reduced in the ER, maintenance of the ER GSH redox state and levels likely depend on ER GSH import and GSSG export. We used quantitative GSH and GS...

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Bibliografiska uppgifter
I publikationen:Mol Cell
Huvudupphovsmän: Ponsero, Alise, Igbaria, Aeid, Darch, Maxwell A., Miled, Samia, Outten, Caryn E., Winther, Jakob R., Palais, Gael, D’autreaux, Benoit, Delaunay-Moisan, Agnes, Toledano, Michel B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772773/
https://ncbi.nlm.nih.gov/pubmed/28918898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.08.012
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