The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum

The Sec61 translocon of the endoplasmic reticulum membrane forms an aqueous pore that is gated by the lumenal Hsp70 chaperone BiP. We have explored the molecular mechanisms governing BiP-mediated gating activity, including the coupling between gating and the BiP ATPase cycle, and the involvement of...

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Hlavní autoři: Alder, Nathan N., Shen, Ying, Brodsky, Jeffrey L., Hendershot, Linda M., Johnson, Arthur E.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2005
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171714/
https://ncbi.nlm.nih.gov/pubmed/15684029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200409174
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