The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum

The Sec61 translocon of the endoplasmic reticulum membrane forms an aqueous pore that is gated by the lumenal Hsp70 chaperone BiP. We have explored the molecular mechanisms governing BiP-mediated gating activity, including the coupling between gating and the BiP ATPase cycle, and the involvement of...

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Autores principales: Alder, Nathan N., Shen, Ying, Brodsky, Jeffrey L., Hendershot, Linda M., Johnson, Arthur E.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2005
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171714/
https://ncbi.nlm.nih.gov/pubmed/15684029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200409174
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