Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation

During the Hsp90-mediated chaperoning of protein kinases, the core components of the machinery, Hsp90 and the cochaperone Cdc37, recycle between different phosphorylation states that regulate progression of the chaperone cycle. We show that Cdc37 phosphorylation at Y298 results in partial unfolding...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Bachman, Ashleigh B., Keramisanou, Dimitra, Xu, Wanping, Beebe, Kristin, Moses, Michael A., Vasantha Kumar, M. V., Gray, Geoffrey, Noor, Radwan Ebna, van der Vaart, Arjan, Neckers, Len, Gelis, Ioannis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772613/
https://ncbi.nlm.nih.gov/pubmed/29343704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02711-w
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