Computational trans-omics approach characterised methylomic and transcriptomic involvements and identified novel therapeutic targets for chemoresistance in gastrointestinal cancer stem cells

We investigated the relationship between methylomic [5-methylation on deoxycytosine to form 5-methylcytosine (5mC)] and transcriptomic information in response to chemotherapeutic 5-fluorouracil (5-FU) exposure and cisplatin (CDDP) administration using the ornithine decarboxylase (ODC) degron-positiv...

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Udgivet i:Sci Rep
Main Authors: Konno, Masamitsu, Matsui, Hidetoshi, Koseki, Jun, Asai, Ayumu, Kano, Yoshihiro, Kawamoto, Koichi, Nishida, Naohiro, Sakai, Daisuke, Kudo, Toshihiro, Satoh, Taroh, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772492/
https://ncbi.nlm.nih.gov/pubmed/29343747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19284-3
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