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The ferroptosis inducer erastin irreversibly inhibits system x(c)− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells
System x(c)(−) was recently described as the most upstream node in a novel form of regulated necrotic cell death, called ferroptosis. In this context, the small molecule erastin was reported to target and inhibit system x(c)(−), leading to cysteine starvation, glutathione depletion and consequently...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5772355/ https://ncbi.nlm.nih.gov/pubmed/29343855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19213-4 |
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