Lipoxygenase‐mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3

In cancer cells the small compounds erastin and RSL3 promote a novel type of cell death called ferroptosis, which requires iron‐dependent accumulation of lipid reactive oxygen species. Here we assessed the contribution of lipid peroxidation activity of lipoxygenases (LOX) to ferroptosis in oncogenic...

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Detalles Bibliográficos
Publicado en:Cancer Sci
Main Authors: Shintoku, Ryosuke, Takigawa, Yuta, Yamada, Keiichi, Kubota, Chisato, Yoshimoto, Yuhei, Takeuchi, Toshiyuki, Koshiishi, Ichiro, Torii, Seiji
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666033/
https://ncbi.nlm.nih.gov/pubmed/28837253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13380
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