Constitutive Reactive Oxygen Species Generation from Autophagosome/Lysosome in Neuronal Oxidative Toxicity

Reactive oxygen species (ROS) are involved in several cell death processes, including cerebral ischemic injury. We found that glutamate-induced ROS accumulation and the associated cell death in mouse hippocampal cell lines were delayed by pharmacological inhibition of autophagy or lysosomal activity...

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Detalhes bibliográficos
Main Authors: Kubota, Chisato, Torii, Seiji, Hou, Ni, Saito, Nobuhito, Yoshimoto, Yuhei, Imai, Hideaki, Takeuchi, Toshiyuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804214/
https://ncbi.nlm.nih.gov/pubmed/19850931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.053058
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