Lipoxygenase‐mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3

In cancer cells the small compounds erastin and RSL3 promote a novel type of cell death called ferroptosis, which requires iron‐dependent accumulation of lipid reactive oxygen species. Here we assessed the contribution of lipid peroxidation activity of lipoxygenases (LOX) to ferroptosis in oncogenic...

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Vydáno v:Cancer Sci
Hlavní autoři: Shintoku, Ryosuke, Takigawa, Yuta, Yamada, Keiichi, Kubota, Chisato, Yoshimoto, Yuhei, Takeuchi, Toshiyuki, Koshiishi, Ichiro, Torii, Seiji
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666033/
https://ncbi.nlm.nih.gov/pubmed/28837253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13380
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