Design, synthesis, cytotoxicity evaluation and docking studies of 1,2,4-triazine derivatives bearing different arylidene-hydrazinyl moieties as potential mTOR inhibitors

Mammalian target of rapamycin (mTOR) is a phosphoinositide 3-kinase-related protein kinase which controls cell growth and is frequently deregulated in many cancers. Therefore, mTOR inhibitors are used as antineoplastic agents for cancer treatment. In this study, 1,2,4-triazine derivatives containing...

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Bibliographic Details
Published in:Res Pharm Sci
Main Authors: Ranjbar, Sara, Edraki, Najmeh, Khoshneviszadeh, Mahsima, Foroumadi, Alireza, Miri, Ramin, Khoshneviszadeh, Mehdi
Format: Artigo
Language:Inglês
Published: Medknow Publications & Media Pvt Ltd 2018
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772076/
https://ncbi.nlm.nih.gov/pubmed/29387106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/1735-5362.220962
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