Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes

Serine/threonine protein phosphatase 5 (PP5) is ubiquitously expressed in eukaryotic cells; however, its function in cardiomyocytes is unknown. Under basal conditions, PP5 is autoinhibited, but enzymatic activity rises upon binding of specific factors, such as the chaperone Hsp90. Here we show that...

Full description

Saved in:
Bibliographic Details
Published in:Nat Commun
Main Authors: Krysiak, Judith, Unger, Andreas, Beckendorf, Lisa, Hamdani, Nazha, von Frieling-Salewsky, Marion, Redfield, Margaret M., dos Remedios, Cris G., Sheikh, Farah, Gergs, Ulrich, Boknik, Peter, Linke, Wolfgang A.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5772059/
https://ncbi.nlm.nih.gov/pubmed/29343782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02483-3
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items