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Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin
The giant protein titin is thought to be required for sarcomeric integrity in mature myocytes, but direct evidence for this hypothesis is limited. Here, we describe a mouse model in which Z-disc-anchored TTN is depleted in adult skeletal muscles. Inactivation of TTN causes sarcomere disassembly and...
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| Pubblicato in: | Nat Commun |
|---|---|
| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7478974/ https://ncbi.nlm.nih.gov/pubmed/32900999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18131-2 |
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