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Structural basis for therapeutic inhibition of complement C5

Activation of complement C5 generates the potent anaphylatoxin C5a and leads to pathogen lysis, inflammation and cell damage. The therapeutic significance of C5 inhibition is demonstrated by Eculizumab, one of the world’s most expensive drugs. However, the mechanism of C5 activation by C5-convertase...

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Dettagli Bibliografici
Pubblicato in:Nat Struct Mol Biol
Autori principali: Jore, Matthijs M., Johnson, Steven, Sheppard, Devon, Barber, Natalie M., Li, Yang I., Nunn, Miles A., Elmlund, Hans, Lea, Susan M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771465/
https://ncbi.nlm.nih.gov/pubmed/27018802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3196
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