Structural basis for therapeutic inhibition of complement C5

Activation of complement C5 generates the potent anaphylatoxin C5a and leads to pathogen lysis, inflammation and cell damage. The therapeutic significance of C5 inhibition is demonstrated by Eculizumab, one of the world’s most expensive drugs. However, the mechanism of C5 activation by C5-convertase...

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Detaylı Bibliyografya
Yayımlandı:Nat Struct Mol Biol
Asıl Yazarlar: Jore, Matthijs M., Johnson, Steven, Sheppard, Devon, Barber, Natalie M., Li, Yang I., Nunn, Miles A., Elmlund, Hans, Lea, Susan M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771465/
https://ncbi.nlm.nih.gov/pubmed/27018802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3196
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