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Structural basis for therapeutic inhibition of complement C5
Activation of complement C5 generates the potent anaphylatoxin C5a and leads to pathogen lysis, inflammation and cell damage. The therapeutic significance of C5 inhibition is demonstrated by Eculizumab, one of the world’s most expensive drugs. However, the mechanism of C5 activation by C5-convertase...
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| Publié dans: | Nat Struct Mol Biol |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5771465/ https://ncbi.nlm.nih.gov/pubmed/27018802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3196 |
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