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Structural basis for therapeutic inhibition of complement C5
Activation of complement C5 generates the potent anaphylatoxin C5a and leads to pathogen lysis, inflammation and cell damage. The therapeutic significance of C5 inhibition is demonstrated by Eculizumab, one of the world’s most expensive drugs. However, the mechanism of C5 activation by C5-convertase...
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| Publicado no: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5771465/ https://ncbi.nlm.nih.gov/pubmed/27018802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3196 |
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