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pKID Binds to KIX via an Unstructured Transition State with Nonnative Interactions

Understanding the detailed mechanism of interaction of intrinsically disordered proteins with their partners is crucial to comprehend their functions in signaling and transcription. Through its interaction with KIX, the disordered pKID region of CREB protein is central in the transcription of cAMP r...

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Vydáno v:Biophys J
Hlavní autoři: Dahal, Liza, Kwan, Tristan O.C., Shammas, Sarah L., Clarke, Jane
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770965/
https://ncbi.nlm.nih.gov/pubmed/29262364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.10.016
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