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pKID Binds to KIX via an Unstructured Transition State with Nonnative Interactions

Understanding the detailed mechanism of interaction of intrinsically disordered proteins with their partners is crucial to comprehend their functions in signaling and transcription. Through its interaction with KIX, the disordered pKID region of CREB protein is central in the transcription of cAMP r...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biophys J
Main Authors: Dahal, Liza, Kwan, Tristan O.C., Shammas, Sarah L., Clarke, Jane
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770965/
https://ncbi.nlm.nih.gov/pubmed/29262364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.10.016
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