Sphingomyelin Metabolism Is a Regulator of K-Ras Function

K-Ras must localize to the plasma membrane (PM) for biological activity. We show here that multiple acid sphingomyelinase (ASM) inhibitors, including tricyclic antidepressants, mislocalized phosphatidylserine (PtdSer) and K-RasG12V from the PM, resulting in abrogation of K-RasG12V signaling and pote...

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Pubblicato in:Mol Cell Biol
Autori principali: van der Hoeven, Dharini, Cho, Kwang-jin, Zhou, Yong, Ma, Xiaoping, Chen, Wei, Naji, Ali, Montufar-Solis, Dina, Zuo, Yan, Kovar, Sarah E., Levental, Kandice R., Frost, Jeffrey A., van der Hoeven, Ransome, Hancock, John F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770534/
https://ncbi.nlm.nih.gov/pubmed/29158292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00373-17
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