The extracellular matrix protein agrin promotes heart regeneration in mice

The adult mammalian heart is non-regenerative owing to the post-mitotic nature of cardiomyocytes. The neonatal mouse heart can regenerate, but only during the first week of life. Here we show that changes in the composition of the extracellular matrix during this week can affect cardiomyocyte growth...

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Veröffentlicht in:Nature
Hauptverfasser: Bassat, Elad, Mutlak, Yara Eid, Genzelinakh, Alex, Shadrin, Ilya Y., Umansky, Kfir Baruch, Yifa, Oren, Kain, David, Rajchman, Dana, Leach, John, Bassat, Daria Riabov, Udi, Yael, Sarig, Rachel, Sagi, Irit, Martin, James F., Bursac, Nenad, Cohen, Shenhav, Tzahor, Eldad
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5769930/
https://ncbi.nlm.nih.gov/pubmed/28581497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22978
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