The extracellular matrix protein agrin promotes heart regeneration in mice

The adult mammalian heart is non-regenerative owing to the post-mitotic nature of cardiomyocytes. The neonatal mouse heart can regenerate, but only during the first week of life. Here we show that changes in the composition of the extracellular matrix during this week can affect cardiomyocyte growth...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Bassat, Elad, Mutlak, Yara Eid, Genzelinakh, Alex, Shadrin, Ilya Y., Umansky, Kfir Baruch, Yifa, Oren, Kain, David, Rajchman, Dana, Leach, John, Bassat, Daria Riabov, Udi, Yael, Sarig, Rachel, Sagi, Irit, Martin, James F., Bursac, Nenad, Cohen, Shenhav, Tzahor, Eldad
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5769930/
https://ncbi.nlm.nih.gov/pubmed/28581497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22978
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