Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)

Antibody-drug conjugates (ADCs) are emerging as effective tools in cancer therapy, combining the antibody's exquisite specificity for the target antigen-expressing cancer cell together with the cytotoxic potency of the payload. Much success stems from the rational design of “toxic warheads”, ch...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Hoffmann, Ricarda M., Coumbe, Ben G. T., Josephs, Debra H., Mele, Silvia, Ilieva, Kristina M., Cheung, Anthony, Tutt, Andrew N., Spicer, James F., Thurston, David E., Crescioli, Silvia, Karagiannis, Sophia N.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2017
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5769674/
https://ncbi.nlm.nih.gov/pubmed/29375935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1395127
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