Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)

Antibody-drug conjugates (ADCs) are emerging as effective tools in cancer therapy, combining the antibody's exquisite specificity for the target antigen-expressing cancer cell together with the cytotoxic potency of the payload. Much success stems from the rational design of “toxic warheads”, ch...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncoimmunology
Main Authors: Hoffmann, Ricarda M., Coumbe, Ben G. T., Josephs, Debra H., Mele, Silvia, Ilieva, Kristina M., Cheung, Anthony, Tutt, Andrew N., Spicer, James F., Thurston, David E., Crescioli, Silvia, Karagiannis, Sophia N.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2017
Teme:
Review
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5769674/
https://ncbi.nlm.nih.gov/pubmed/29375935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1395127
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