Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)

Antibody-drug conjugates (ADCs) are emerging as effective tools in cancer therapy, combining the antibody's exquisite specificity for the target antigen-expressing cancer cell together with the cytotoxic potency of the payload. Much success stems from the rational design of “toxic warheads”, ch...

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Bibliographic Details
Published in:Oncoimmunology
Main Authors: Hoffmann, Ricarda M., Coumbe, Ben G. T., Josephs, Debra H., Mele, Silvia, Ilieva, Kristina M., Cheung, Anthony, Tutt, Andrew N., Spicer, James F., Thurston, David E., Crescioli, Silvia, Karagiannis, Sophia N.
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2017
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5769674/
https://ncbi.nlm.nih.gov/pubmed/29375935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1395127
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