USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A

BRCA1-BARD1-catalyzed ubiquitination of histone H2A is an important regulator of the DNA damage response, priming chromatin for repair by homologous recombination. However, no specific deubiquitinating enzymes (DUBs) are known to antagonize this function. Here we identify ubiquitin specific protease...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Uckelmann, Michael, Densham, Ruth M., Baas, Roy, Winterwerp, Herrie H. K., Fish, Alexander, Sixma, Titia K., Morris, Joanna R.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768779/
https://ncbi.nlm.nih.gov/pubmed/29335415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02653-3
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars