USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A

BRCA1-BARD1-catalyzed ubiquitination of histone H2A is an important regulator of the DNA damage response, priming chromatin for repair by homologous recombination. However, no specific deubiquitinating enzymes (DUBs) are known to antagonize this function. Here we identify ubiquitin specific protease...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Uckelmann, Michael, Densham, Ruth M., Baas, Roy, Winterwerp, Herrie H. K., Fish, Alexander, Sixma, Titia K., Morris, Joanna R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768779/
https://ncbi.nlm.nih.gov/pubmed/29335415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02653-3
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