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The DUSP–Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange
Ubiquitin-specific protease USP4 is emerging as an important regulator of cellular pathways, including the TGF-β response, NF-κB signalling and splicing, with possible roles in cancer. Here we show that USP4 has its catalytic triad arranged in a productive conformation. Nevertheless, it requires its...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Pub. Group
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4243247/ https://ncbi.nlm.nih.gov/pubmed/25404403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6399 |
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