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USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling
SMAD4 is a common intracellular effector for TGF‐β family cytokines, but the mechanism by which its activity is dynamically regulated is unclear. We demonstrated that ubiquitin‐specific protease (USP) 4 strongly induces activin/BMP signaling by removing the inhibitory monoubiquitination from SMAD4....
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5452037/ https://ncbi.nlm.nih.gov/pubmed/28468752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695372 |
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