USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling

SMAD4 is a common intracellular effector for TGF‐β family cytokines, but the mechanism by which its activity is dynamically regulated is unclear. We demonstrated that ubiquitin‐specific protease (USP) 4 strongly induces activin/BMP signaling by removing the inhibitory monoubiquitination from SMAD4....

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Detaylı Bibliyografya
Yayımlandı:EMBO J
Asıl Yazarlar: Zhou, Fangfang, Xie, Feng, Jin, Ke, Zhang, Zhengkui, Clerici, Marcello, Gao, Rui, van Dinther, Maarten, Sixma, Titia K, Huang, Huizhe, Zhang, Long, ten Dijke, Peter
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2017
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5452037/
https://ncbi.nlm.nih.gov/pubmed/28468752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695372
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