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Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors
MCL1 is a pivot member of the anti-apoptotic BCL-2 family proteins. While a distinctive feature of MCL1 resides in its efficient ubiquitination and destruction, the deubiquitinase USP9X has been implicated in the preservation of MCL1 expression by removing the polyubiquitin chains. Here we perform a...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5768685/ https://ncbi.nlm.nih.gov/pubmed/29335437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02693-9 |
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