Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors

MCL1 is a pivot member of the anti-apoptotic BCL-2 family proteins. While a distinctive feature of MCL1 resides in its efficient ubiquitination and destruction, the deubiquitinase USP9X has been implicated in the preservation of MCL1 expression by removing the polyubiquitin chains. Here we perform a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Zhang, Shengzhe, Zhang, Meiying, Jing, Ying, Yin, Xia, Ma, Pengfei, Zhang, Zhenfeng, Wang, Xiaojie, Di, Wen, Zhuang, Guanglei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768685/
https://ncbi.nlm.nih.gov/pubmed/29335437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02693-9
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