Design and Synthesis of Isoquinolidinobenzodiazepine Dimers, a Novel Class of Antibody–Drug Conjugate Payload

[Image: see text] Antibody–drug conjugates (ADCs) represent an important class of emerging cancer therapeutics. Recent ADC development efforts highlighted the use of pyrrolobenzodiazepine (PBD) dimer payload for the treatment of several cancers. We identified the isoquinolidinobenzodiazepine (IQB) p...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Smith, Sean W., Jammalamadaka, Vasu, Borkin, Dmitry, Zhu, Jianyu, Degrado, Sylvia J., Lu, Jennifer, Huang, Jianqing, Jiang, Ying-Ping, Jain, Nareshkumar, Junutula, Jagath R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767884/
https://ncbi.nlm.nih.gov/pubmed/29348812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00436
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