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Design and Synthesis of Isoquinolidinobenzodiazepine Dimers, a Novel Class of Antibody–Drug Conjugate Payload
[Image: see text] Antibody–drug conjugates (ADCs) represent an important class of emerging cancer therapeutics. Recent ADC development efforts highlighted the use of pyrrolobenzodiazepine (PBD) dimer payload for the treatment of several cancers. We identified the isoquinolidinobenzodiazepine (IQB) p...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | ACS Med Chem Lett |
|---|---|
| Prif Awduron: | , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Chemical
Society
2017
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| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5767884/ https://ncbi.nlm.nih.gov/pubmed/29348812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00436 |
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