Design and Synthesis of Isoquinolidinobenzodiazepine Dimers, a Novel Class of Antibody–Drug Conjugate Payload

[Image: see text] Antibody–drug conjugates (ADCs) represent an important class of emerging cancer therapeutics. Recent ADC development efforts highlighted the use of pyrrolobenzodiazepine (PBD) dimer payload for the treatment of several cancers. We identified the isoquinolidinobenzodiazepine (IQB) p...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Med Chem Lett
Prif Awduron: Smith, Sean W., Jammalamadaka, Vasu, Borkin, Dmitry, Zhu, Jianyu, Degrado, Sylvia J., Lu, Jennifer, Huang, Jianqing, Jiang, Ying-Ping, Jain, Nareshkumar, Junutula, Jagath R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2017
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767884/
https://ncbi.nlm.nih.gov/pubmed/29348812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00436
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