Design and Synthesis of Isoquinolidinobenzodiazepine Dimers, a Novel Class of Antibody–Drug Conjugate Payload

[Image: see text] Antibody–drug conjugates (ADCs) represent an important class of emerging cancer therapeutics. Recent ADC development efforts highlighted the use of pyrrolobenzodiazepine (PBD) dimer payload for the treatment of several cancers. We identified the isoquinolidinobenzodiazepine (IQB) p...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Smith, Sean W., Jammalamadaka, Vasu, Borkin, Dmitry, Zhu, Jianyu, Degrado, Sylvia J., Lu, Jennifer, Huang, Jianqing, Jiang, Ying-Ping, Jain, Nareshkumar, Junutula, Jagath R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2017
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767884/
https://ncbi.nlm.nih.gov/pubmed/29348812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00436
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