Distinct B subunits of PP2A regulate the NF‐κB signalling pathway through dephosphorylation of IKKβ, IκBα and RelA

PP2A is composed of a scaffolding subunit (A), a catalytic subunit (C) and a regulatory subunit (B) that is classified into four families including B, B′, B′′ and B′′′/striatin. Here, we found that a distinct PP2A complex regulates NF‐κB signalling by dephosphorylation of IKKβ, IκBα and RelA/p65. Th...

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Detalhes bibliográficos
Publicado no:FEBS Lett
Main Authors: Tsuchiya, Yoshihiro, Osaki, Keiko, Kanamoto, Mayu, Nakao, Yuki, Takahashi, Ena, Higuchi, Toru, Kamata, Hideaki
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Letters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767752/
https://ncbi.nlm.nih.gov/pubmed/29139553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12912
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