Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding

IKKβ, an essential kinase of NF-κB signaling, is composed of an N-terminal kinase domain (KD) and a C-terminal scaffolding domain, containing a ubiquitin-like domain (ULD). The Hsp90 chaperon has special responsibility for folding of protein kinases including IKKβ. Here, we found that Hsp90 inhibiti...

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Bibliographic Details
Published in:PLoS One
Main Authors: Kanamoto, Mayu, Tsuchiya, Yoshihiro, Nakao, Yuki, Suzuki, Takafumi, Motohashi, Hozumi, Yamamoto, Masayuki, Kamata, Hideaki
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6267955/
https://ncbi.nlm.nih.gov/pubmed/30500824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203978
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