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Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding
IKKβ, an essential kinase of NF-κB signaling, is composed of an N-terminal kinase domain (KD) and a C-terminal scaffolding domain, containing a ubiquitin-like domain (ULD). The Hsp90 chaperon has special responsibility for folding of protein kinases including IKKβ. Here, we found that Hsp90 inhibiti...
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| Gepubliceerd in: | PLoS One |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6267955/ https://ncbi.nlm.nih.gov/pubmed/30500824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203978 |
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