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Properties of Purified CYP2R1 in a Reconstituted Membrane Environment and its 25-Hydroxylation of 20-Hydroxyvitamin D3

Recent studies indicate that CYP2R1 is the major 25-hydroxylase catalyzing the first step in vitamin D activation. Since the catalytic properties of CYP2R1 have been poorly studied to date and it is a membrane protein, we examined the purified enzyme in a membrane environment. CYP2R1 was expressed i...

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Detalhes bibliográficos
Publicado no:J Steroid Biochem Mol Biol
Main Authors: Cheng, Chloe Y. S., Kim, Tae-Kang, Jeayeng, Saowanee, Slominski, Andrzej T., Tuckey, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767547/
https://ncbi.nlm.nih.gov/pubmed/28716760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2017.07.011
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