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Preparation of Stable Amyloid β-Protein Oligomers of Defined Assembly Order

Oligomeric assemblies of the amyloid β-protein, Aβ, are thought to be the proximate neurotoxic agents in Alzheimer’s disease (AD). Oligomer formation is a complex process that produces a polydisperse population of metastable structures. For this reason, formal structure–activity correlations, both i...

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Detalhes bibliográficos
Publicado no:Methods Mol Biol
Main Authors: Rosensweig, Clark, Ono, Kenjiro, Murakami, Kazuma, Lowenstein, Devin K., Bitan, Gal, Teplow, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767166/
https://ncbi.nlm.nih.gov/pubmed/22528081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-61779-551-0_3
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