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Mechanism of polypurine tract primer generation by HIV-1 reverse transcriptase

HIV-1 reverse transcriptase (RT) possesses both DNA polymerase activity and RNase H activity that act in concert to convert single-stranded RNA of the viral genome to double-stranded DNA that is then integrated into the DNA of the infected cell. Reverse transcriptase–catalyzed reverse transcription...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Figiel, Małgorzata, Krepl, Miroslav, Park, Sangwoo, Poznański, Jarosław, Skowronek, Krzysztof, Gołąb, Agnieszka, Ha, Taekjip, Šponer, Jiří, Nowotny, Marcin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766924/
https://ncbi.nlm.nih.gov/pubmed/29122886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.798256
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