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Interaction of the phosphorylated DNA-binding domain in nuclear receptor CAR with its ligand-binding domain regulates CAR activation

The nuclear protein constitutive active/androstane receptor (CAR or NR1I3) regulates several liver functions such as drug and energy metabolism and cell growth or death, which are often involved in the development of diseases such as diabetes and hepatocellular carcinoma. CAR undergoes a conversion...

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Foilsithe in:J Biol Chem
Main Authors: Shizu, Ryota, Min, Jungki, Sobhany, Mack, Pedersen, Lars C., Mutoh, Shingo, Negishi, Masahiko
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766923/
https://ncbi.nlm.nih.gov/pubmed/29133527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.806604
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