Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding

Domain-minimized insulin receptors (IRs) have enabled crystallographic analysis of insulin-bound “micro-receptors.” In such structures, the C-terminal segment of the insulin B chain inserts between conserved IR domains, unmasking an invariant receptor-binding surface that spans both insulin A and B...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Glidden, Michael D., Yang, Yanwu, Smith, Nicholas A., Phillips, Nelson B., Carr, Kelley, Wickramasinghe, Nalinda P., Ismail-Beigi, Faramarz, Lawrence, Michael C., Smith, Brian J., Weiss, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766920/
https://ncbi.nlm.nih.gov/pubmed/29114034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.808667
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