JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension

The hypoxic response is a stress response triggered by low oxygen tension. Hypoxia-inducible factors (HIFs) play a prominent role in the pathobiology of hypoxia-associated conditions, including pulmonary hypertension (PH) and polycythemia. The c-Jun N-terminal protein kinase (JNK), a stress-activate...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Sala, Marc A., Chen, Cong, Zhang, Qiao, Do-Umehara, Hanh Chi, Wu, Wenjiao, Misharin, Alexander V., Waypa, Gregory B., Fang, Deyu, Budinger, G. R. Scott, Liu, Shuwen, Chandel, Navdeep S., Schumacker, Paul T., Sznajder, Jacob I., Liu, Jing
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766905/
https://ncbi.nlm.nih.gov/pubmed/29118187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000440
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