Jnk2 promotes stress-induced mitophagy and suppresses inflammasome activation by targeting smARF for degradation

Mitophagy is essential for cellular homeostasis but the regulatory mechanism is largely unknown. Here we report that the kinase Jnk2 is required for stress-induced mitophagy. Jnk2 promoted ubiquitination and proteasomal degradation of small mitochondrial form of ARF (smARF). Loss of Jnk2 led to accu...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Zhang, Qiao, Kuang, Hong, Chen, Cong, Yan, Jie, Do-Umehara, Hanh Chi, Liu, Xin-yuan, Dada, Laura, Ridge, Karen M., Chandel, Navdeep S., Liu, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451949/
https://ncbi.nlm.nih.gov/pubmed/25799126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3130
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