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Mitochondrial Reactive Oxygen Species Trigger Hypoxia-Inducible Factor-Dependent Extension of the Replicative Life Span during Hypoxia

Physiological hypoxia extends the replicative life span of human cells in culture. Here, we report that hypoxic extension of replicative life span is associated with an increase in mitochondrial reactive oxygen species (ROS) in primary human lung fibroblasts. The generation of mitochondrial ROS is n...

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Detalhes bibliográficos
Main Authors: Bell, Eric L., Klimova, Tatyana A., Eisenbart, James, Schumacker, Paul T., Chandel, Navdeep S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952129/
https://ncbi.nlm.nih.gov/pubmed/17562866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02265-06
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