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The Q(o) site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production
Mammalian cells increase transcription of genes for adaptation to hypoxia through the stabilization of hypoxia-inducible factor 1α (HIF-1α) protein. How cells transduce hypoxic signals to stabilize the HIF-1α protein remains unresolved. We demonstrate that cells deficient in the complex III subunit...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2064363/ https://ncbi.nlm.nih.gov/pubmed/17562787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200609074 |
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