The Q(o) site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

Mammalian cells increase transcription of genes for adaptation to hypoxia through the stabilization of hypoxia-inducible factor 1α (HIF-1α) protein. How cells transduce hypoxic signals to stabilize the HIF-1α protein remains unresolved. We demonstrate that cells deficient in the complex III subunit...

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Huvudupphovsmän: Bell, Eric L., Klimova, Tatyana A., Eisenbart, James, Moraes, Carlos T., Murphy, Michael P., Budinger, G.R. Scott, Chandel, Navdeep S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2007
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064363/
https://ncbi.nlm.nih.gov/pubmed/17562787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200609074
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