Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168

The E3 ubiquitin (Ub) ligase RNF168 plays a critical role in the initiation of the DNA damage response to double-strand breaks (DSBs). The recruitment of RNF168 by ubiquitylated targets involves two distinct regions, Ub-dependent DSB recruitment module (UDM) 1 and UDM2. Here we report the crystal st...

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Vydáno v:Nat Commun
Hlavní autoři: Takahashi, Tomio S., Hirade, Yoshihiro, Toma, Aya, Sato, Yusuke, Yamagata, Atsushi, Goto-Ito, Sakurako, Tomita, Akiko, Nakada, Shinichiro, Fukai, Shuya
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766498/
https://ncbi.nlm.nih.gov/pubmed/29330428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02345-y
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