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Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168
The E3 ubiquitin (Ub) ligase RNF168 plays a critical role in the initiation of the DNA damage response to double-strand breaks (DSBs). The recruitment of RNF168 by ubiquitylated targets involves two distinct regions, Ub-dependent DSB recruitment module (UDM) 1 and UDM2. Here we report the crystal st...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5766498/ https://ncbi.nlm.nih.gov/pubmed/29330428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02345-y |
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