Leptin mediates a glucose-fatty acid cycle to maintain glucose homeostasis in starvation

The transition from the fed to the fasted state necessitates a shift from carbohydrate to fat metabolism, which is thought to be mostly orchestrated by reductions in plasma insulin concentrations. Here we show in awake rats that insulinopenia per se does not cause this transition, but that both hypo...

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Udgivet i:Cell
Main Authors: Perry, Rachel J., Wang, Yongliang, Cline, Gary W., Rabin-Court, Aviva, Song, Joongyu D., Dufour, Sylvie, Zhang, Xian-Man, Petersen, Kitt Falk, Shulman, Gerald I.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766366/
https://ncbi.nlm.nih.gov/pubmed/29307489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.12.001
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